Has your bottom, thigh, or leg ever started hurting before, during, or after a genital herpes outbreak? Leg pain is more common than you think when living with genital herpes (HSV-2). Other sensations include numbness, tingling, skin sensitivity, overall leg weakness, and shooting pains. For example, when you have sensitive skin, sitting on a cold toilet seat can cause discomfort in the back of your thighs. These sensations are similar to those caused by sciatica and can spread as far as your feet. It's caused by irritated nerves that have become sensitized as the herpes virus travels through your nerve ganglia. When these symptoms persist, it is called Postherpetic Neuralgia and is considered a complication of the Herpes Simplex Virus.